Nejm case of the week ” A diagnosis was 4 days ago · CME activities, cases, challenges, videos, and more teaching and learning tools from the New England Journal of Medicine. We explore the genetics behind misdiagnosed common diseases and review uncertainty in medical training. Tufts College Medical School, 1936. Oct 29, 2025 · NEJM This Week — November 20, 2025 This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice. 23). Nestor (Medicine): A 63-year-old woman was evaluated at this hospital because of dyspnea on exertion that had persisted for 2 months. Aug 22, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — August 22, 2024 Jul 10, 2025 · Explore this issue of The New England Journal of Medicine (Vol. After a ventricular assist device was placed and anticoagulation therapy initiated, he Jul 18, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — July 18, 2024 NEJM This Week podcast on demand - Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). Jacquelyn M. Parthasarathy and G. B. An extensive workup was unrevealing. NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. Apr 10, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — April 10, 2025 Jun 20, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 20, 2024 May 9, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — May 9, 2024 The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. 1056/NEJMcpc2027093. Metastatic melanoma was diagnosed, and treatment Jun 28, 2023 · A 52-year-old man with a metastatic solitary fibrous tumor was admitted for hypoglycemia. NEJM Group podcasts further our organization's mission to transform health care practices around the world through valuable medical research and timely dialogue about the changing health care landscape. 5 days ago · This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. Aug 21, 2024 · A 59-year-old woman was referred for evaluation of a breast lesion of 27 years’ duration. A purpuric rash was present on the abdomen. He had a 1-year history of recurrent diarrhea and an enterocolonic fistula. Nov 12, 2025 · Explore this issue of The New England Journal of Medicine (Vol. Methotrexate, which is recommended as a second-line treatment, ap Oct 16, 2024 · A 72-year-old woman with a history of dyspnea on exertion and edema in both legs was admitted to the hospital with dysarthria and rapidly evolving respiratory failure. Levels of insulin, C-peptide, and β-hydroxybutyrate were undetectable. The examination was notable for rash, nasal crusting, and alopecia. van’t Hof and Others DOI:10. Shappell and Others Explore the current issue of The New England Journal of Medicine (Vol. D. The patient died on the fourth hospital day. Jan 30, 2025 · Featuring articles on heart failure and obesity, oral anticoagulation during TAVI, hemophilia A, hereditary angioedema, and tuberculosis; a review article on sport-related concussion; a case Jul 25, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — July 25, 2024 Jan 16, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — January 16, 2025 Oct 9, 2025 · NEJM This Week — October 23, 2025 In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept for early pulmonary arterial hypertension. Oct 28, 2025 · Explore Cases articles from NEJM EvidenceThis report examines the story of a 40-year-old woman who presented to the emergency department for evaluation of chest pain and pain in the joints of her hands and feet. Sep 4, 2024 · One hundred years ago, a 24-year-old man was admitted to the hospital because of fever, cough, and shortness of breath. Oct 8, 2025 · Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. 4). A diag Nov 10, 2025 · A. 9%. We review long QT syndrome and present a case of abnormal behavior and seizures… 4 days ago · Explore Images in Clinical Medicine articles from The New England Journal of Medicine Jul 2, 2025 · Benchmarked against real-world case records published each week in the New England Journal of Medicine, we show that the Microsoft AI Diagnostic Orchestrator (MAI-DxO) correctly diagnoses up to 85% of NEJM case proceedings, a rate more than four times higher than a group of experienced physicians. A diagnosis was made. Using questions, physical examination, and testing, an illness script for the presentation emerges; the differential is refined until a final 5 days ago · A case study of a collaboration between a maternity care provider organization and a large health insurer in the Netherlands to develop an outcomes-based payment model to advance value-based maternity care. The body temperature was 38. New Manuscripts Welcome and thank you for considering the New England Journal of Medicine (NEJM) as a venue for your work. Imaging showed pulmonary opacities, and the hematocrit was 56. Intern at the Rhode Island Hospital. Our podcasts feature conversations with frontline clinicians, patients, leading researchers, and world-renowned health care experts. Jan 15, 2025 · A 21-year-old man with sickle cell disease was evaluated after loss of consciousness resulting in a fall. NEJM Group, a division of MMS, creates high-quality medical resources for research, learning, practice and professional development designed to meet the demand for essential medical knowledge among academic researchers and teachers, physicians, clinicians, executives and others in medicine and health care. . Case Records of the Massachusetts General Hospital Case 8-2025: A 72-Year-Old Woman with Altered Mental Status and Acidemia P. Jan 16, 2025 · Case Records of the Massachusetts General Hospital Case 2-2025: A 21-Year-Old Man with Loss of Consciousness and a Fall E. Edlow, A. MRI showed diffuse subarachnoid h Jan 23, 2025 · Featuring articles on esophageal cancer, out-of-hospital cardiac arrest, and atrial fibrillation; a review article on the physiology of hunger; a case report of a man with exertional dyspnea and NEJM Group podcasts further our organization's mission to transform health care practices around the world through valuable medical research and timely dialogue about the changing health care landscape. We review noninvasive liver fibrosis assessment and a complex clinical case, and explore perspectives on concierge care, kidney disease equity, WIC enrollment, community health, FDA Jul 18, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — July 18, 2024 NEJM This Week podcast on demand - Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. In the hospital, the patient struck a staff member and said, “I thought they were trying to kill me. doi: 10. 22). In this episode, we discuss long-term outcomes after Apr 17, 2024 · A 58-year-old woman was transferred to the hospital after 16 months of waxing and waning confusion and aphasia and evolving changes on MRI of the head. Jul 24, 2025 · Explore Interactive Medical Case articles from The New England Journal of Medicine Apr 17, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — April 17, 2025 Feb 12, 2025 · A 30-year-old woman was admitted to the hospital because of headache and dysesthesia. Jun 30, 2025 · Benchmarked against real-world case records published each week in the New England Journal of Medicine, we show that the Microsoft AI Diagnostic Orchestrator (MAI-DxO) correctly diagnoses up to 85% of NEJM case proceedings, a rate more than four times higher than a group of experienced physicians. 1056/EVIDoa2500268 Nov 13, 2025 · NEJM This Week — November 13, 2025 In this episode, we look at new trials on deferring arterial catheterization in shock, beta-blocker use after myocardial infarction, and a treatment for triple Mar 18, 2020 · A 64-year-old man with a history of melanoma presented to the hospital after evaluation for clumsiness of the right arm had revealed a brain mass. Mar 10, 2021 · A 19-year-old man was admitted to the pediatric ICU because of shock, multiple organ failure, and rash. NEJM Image Challenge dataset and experiments. May 7, 2025 · A 70-year-old man was admitted to the hospital for weakness, anorexia, and weight loss. Jun 25, 2025 · Presentation of Case Dr. A. A 4 days ago · CME activities, cases, challenges, videos, and more teaching and learning tools from the New England Journal of Medicine. Which Nov 13, 2025 · A 56-year-old man was admitted to the hospital because of left lower abdominal pain and anemia. M. Physical examination was notable for tenderness over the lumbar spine and a normal neurologic Sep 8, 2022 · Audio summary from the New England Journal of Medicine — NEJM This Week — September 8, 2022 Oct 9, 2024 · A 37-year-old man was transferred to the hospital because of fever, myalgia, and hypoxemia. Nov 27, 2024 · A 41-year-old man with epilepsy presented with increased seizure activity. She had hyperreflexia and impaired attention and memory. Morning Report A 62-Year-Old Woman with Diarrhea after Hematopoietic Stem-Cell Transplantation E. He had recently travelled from the United States to visit family in Cambodia. Singhal, and J. The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. Suárez and Others Clinical Trials Case Study Patient–Stakeholder Engagement for Patient-Centered Research on Sleep Apnea S. Management decisions were made. She had recently traveled to Asia and Hawaii. On examination, a large, fungating mass with bleeding was present in the right breast. We have chosen the cases in this collection based on their clinical relevance to primary care. Jan 10, 2022 · This report examines the story of a 66-year-old man with Parkinson’s disease and hypertension who presented to the emergency department with fever and confusion. As demand for Dec 12, 2024 · Explore this issue of The New England Journal of Medicine (Vol. Oct 2, 2025 · Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). W. Physical examination revealed jugular venous distention and Kussmaul’s sign. Chest imaging and thoracentesis findings confirmed the presence of an exudative right pleural effusion. Find the answers in the full text of the case, to be published in the August 21/28, 2025, issue. Nov 13, 2024 · A full-term infant was admitted to the neonatal intensive care unit for hypoxemic respiratory failure. Jun 12, 2025 · Five days before the onset of the rash, the patient had completed a 2-week course of systemic glucocorticoids to treat side effects of chemotherapy. 392 No. W. 0 No. Explore the current issue of The New England Journal of Medicine (Vol. 2 days ago · Explore this issue of The New England Journal of Medicine (Vol. THIS WEEK'S ISSUE Contains articles by the following named authors : Howe, C. Oct 2, 2025 · A 51-year-old man presented with 1 week of nonproductive cough and dyspnea that limited his ability to climb stairs, previously done with ease. During the third week, a chest radiograph showed a persistent opacity in the left lower lobe. 20). Biopsy showed hepatocellular carcinoma. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-li Jan 22, 2025 · A 54-year-old male athlete was evaluated at this hospital because of exertional dyspnea and chest pain. Jun 27, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 27, 2024 Apr 30, 2025 · Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Evaluation revealed leukocytosis, acute kidney failure, and conjugated hyperbilirubinemia. 1056/EVIDoa2500268 Jul 1, 2025 · "Benchmarked against real-world case records published each week in the New England Journal of Medicine, we show that the Microsoft AI Diagnostic Orchestrator (MAI-DxO) correctly diagnoses up to 85% of NEJM case proceedings, a rateآ more than four times higher than a group of experienced physicians. A diagnosis was Nov 24, 2021 · In this report from Qatar, the severity of SARS-CoV-2 second infections was investigated. 393 No. In this ongoing phase 3, multicenter Jun 19, 2024 · A 46-year-old man was evaluated in the rheumatology clinic because of joint pain and swelling. Oct 23, 2025 · NEJM This Week — October 23, 2025 In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept Nov 6, 2025 · NEJM This Week — November 6, 2025 In this episode, we discuss long-term outcomes after chest-wall irradiation for breast cancer, new treatments for psoriasis and obesity, and early results on a Jun 26, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 26, 2025 Oct 9, 2025 · NEJM This Week — October 9, 2025 In this episode, we explore new treatments for hypertension, hereditary amyloidosis, and malaria prevention, along with insights on mosquito-borne disease control. 8 The need for oversight of such clinics and for the education Case Records of the Massachusetts General Hospital J. 391 No. Feb 7, 2025 · In a phase 3, randomized, controlled trial, we assigned adults with biopsy-proven active lupus nephritis in a 1:1 ratio to receive obinutuzumab in one of two dose schedules (1000 mg on day 1 and Apr 9, 2025 · A 32-year-old woman was admitted with flank pain, fever, and hypoxemia. Apr 25, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — April 25, 2024 Jun 4, 2022 · Obesity is a chronic disease that results in substantial global morbidity and mortality. Jul 24, 2025 · Explore this issue of The New England Journal of Medicine (Vol. Frydman Tomorrow’s Trial Mar 11, 2021 · Case 7-2021: A 19-Year-Old Man with Shock, Multiple Organ Failure, and RashN Engl J Med. U. We hope you find this collection engaging and instructive. NEJM publishes new medical research findi 5 days ago · Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). Sep 22, 2021 · Controls were defined on the basis of a negative PCR test for SARS-CoV-2, regardless of symptoms, and were matched to cases according to the week of the test date and site. Twenty hours before admission, abdominal pain and nausea developed after he ate leftovers fro Nov 14, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — November 14, 2024 Jul 23, 2025 · A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. May 15, 2020 · In case series, approximately 5% of patients with severe Covid-19 have received renal-replacement therapy 34; the pathophysiology of the renal failure is currently unclear but is probably Feb 14, 2024 · A 36-year-old man was evaluated in the infectious diseases clinic of the hospital because of fevers and throat discomfort that had begun 18 days earlier. A growth of pink tissue at the umbilicus that seeped yellow liquid was noted. May 28, 2025 · A 52-year-old man was evaluated in a hospital in Argentina for fever and hypoxemic respiratory failure. Jul 6, 2025 · “Medical Superintelligence” Benchmarked against real-world case records published each week in the New England Journal of Medicine, we show that the Microsoft AI Diagnostic Orchestrator (MAI-DxO) correctly diagnoses up to 85% of NEJM case proceedings, a rate more than four times higher than a group of experienced physicians. F. Oct 22, 2025 · This week, we look at new findings from the European prostate cancer screening study, advances in lung cancer therapy, physical therapy for meniscal tear, and a promising vaccine for Salmonella Paratyphi A. NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and Apr 23, 2025 · A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and a pruritic rash on her face, chest, abdomen, and legs. 2). Imaging showed multifocal pulmonary opacities, pulmonary embolism, and renal vein thromboses. Jul 23, 2025 · A 75-year-old man was admitted to the hospital because of dyspnea and hypoxemia. A diagnosis Mar 27, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — March 27, 2025 Oct 9, 2024 · A 37-year-old man was transferred to the hospital because of fever, myalgia, and hypoxemia. MRI of the head showed no clinically significant hemorrhage or evidence of restricted diffu Feb 27, 2025 · A 62-year-old man presented with a 5-day history of low back pain and a 1-day history of lethargy. Rapidly progressive altered mental status developed shortly after admission. On the return flight, his speech became incoherent, and he had rhythmic shaking movements of the arms and legs without gaze deviation, incontinence, or Apr 16, 2025 · A 79-year-old woman was evaluated for cough and weight loss. Romero N Engl J Med 2024;390:2108-2118 Dec 9, 2010 · Patients were randomly assigned to undergo hemodialysis six times per week (frequent hemodialysis, 125 patients) or three times per week (conventional hemodialysis, 120 patients) for 12 months Feb 19, 2025 · A 62-year-old man was admitted because of postprandial abdominal pain and weight loss. CT of the chest showed a cavitary lesion in the right upper lobe and masses in both lower lobes. Mar 26, 2025 · A 59-year-old man with a history of metabolic dysfunction–associated steatotic liver disease had an enlarging liver mass. The severity of illness associated with second infections was much lower than that associated with initial Microsoft’s approach is to use clinical case reports from the New England Journal of Medicine (NEJM), which detail the full diagnostic journey: patient presentation, tests ordered, information gathered, and the evolving thought process behind each step. Shappell and Others Oct 16, 2025 · NEJM This Week — October 16, 2025 In this episode, we look at new research in cervical cancer, lupus, gene therapy for immune deficiency, and malaria prevention in infants. We evaluated strategies of peanut Jun 22, 2023 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 22, 2023 Nov 10, 2025 · A. Nov 5, 2025 · Listen to NEJM This Week — November 6, 2025 from NEJM This Week (18 min) • Published Nov 5, 2025. Jan 30, 2025 · Explore this issue of The New England Journal of Medicine (Vol. May 18, 2025 · Prednisone is currently recommended as the first-line treatment for pulmonary sarcoidosis but is associated with many side effects. Jul 21, 2021 · A 64-year-old woman was admitted with a 6-week history of cognitive impairment, headache, and memory loss. … Each interactive case presents an The New England Journal of Medicine NEJM Evidence NEJM AI NEJM Catalyst NEJM Journal Watch Jun 5, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 5, 2025 NEJM seeks submissions of original research, reviews, case reports, and commentaries that improve patient care and clinical practice, or that offer new information about the biology of disease. Feb 26, 2015 · The prevalence of peanut allergy among children in Western countries has doubled in the past 10 years, and peanut allergy is becoming apparent in Africa and Asia. Dec 5, 2024 · Explore this issue of The New England Journal of Medicine (Vol. We also explore perspectives on primary care reform, tobacco cessation in HIV 4 days ago · This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare Feb 27, 2025 · Featuring articles on H5N1 infection, chronic subdural hematoma, achondroplasia, and B-cell acute lymphoblastic leukemia; a review article on carceral health care; a case report of a woman with Sep 12, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — September 12, 2024 Jan 24, 2024 · An 8-week-old male infant was admitted with irritability that had progressed over a period of 7 days. Cirrhosis had reportedly been diagnosed 1 year earlier; imaging showed portal vein thrombosis. Who Should Participate NEJM Weekly CME exam and Interactive Medical Case activities are designed for practicing physicians who wish to advance their knowledge of current clinical medicine Jun 18, 2025 · A 61-year-old man presented with hypoxemic respiratory failure and shock 10 weeks after kidney transplantation. 2021 Mar 11;384 (10):953-963. Nov 28, 2018 · A 36-year-old man was admitted to the intensive care unit with an acute exacerbation of chronic heart failure. Contribute to cx0/nejm-image-challenge development by creating an account on GitHub. After admission, lethargy, hypoxemia, and hypotonia developed. Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). 2°C, and heart Jun 19, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — June 19, 2025 Sep 11, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — September 11, 2025 Sep 5, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — September 5, 2024 Mar 30, 2017 · The New England Journal of Medicine publishes several case-based series including Case Records of the Massachusetts General Hospital, Clinical Problem-Solving, and Clinical Practice, plus our online Interactive Medical Cases. 0). Simic and Others Mar 16, 2017 · Other case reports have shown a lack of efficacy in cases of medical tourism in which nothing was injected into the patient’s eye. The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of A 76-year-old man with coronary artery disease and heart failure with reduced ejection fraction presented to clinic with an 8-month history of progressive breast enlargement and tenderness. A Dec 21, 2023 · Image Challenge December 21, 2023 A 25-year-old woman with severe obesity presented to the emergency department with a 1-week history of blurred vision, headaches, and transient visual obscurations. MAI-DxO also gets to the correct diagnosis more cost-effectively than physicians. May 15, 2025 · A single-patient, expanded-access Investigational New Drug application was submitted to the FDA when the patient was 6 months of age, which was approved 1 week later. We review long QT syndrome and present a case of abnormal behavior and seizures in a Feb 26, 2025 · What is the diagnosis? Cast your vote. We review long QT syndrome and present a case of abnormal behavior and seizures in a young man. J. 19). Feb 20, 2025 · Audio summary from the New England Journal of Medicine — NEJM This Week — February 20, 2025 Sep 19, 2024 · Audio summary from the New England Journal of Medicine — NEJM This Week — September 19, 2024 Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). آ MAI-DxO also gets to the correct diagnosis Jan 16, 2025 · Case Records of the Massachusetts General Hospital Case 2-2025: A 21-Year-Old Man with Loss of Consciousness and a Fall E. 4 days ago · A 1-week-old full-term baby boy was brought to the hospital for evaluation of discharge from his navel. M. 5).